Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone.

AVC | Critically appraised articles
:
Purssell E. Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone. Arch Dis Child. 2011;96:1175-9. D.O.I.: 10.1136/archdischild-2011-300424.

Reviewers: Llerena Santa Cruz E¹, Guarch Ibáñez B², Buñuel Álvarez JC<sup>3

1</sup> Hospital Universitario Dr. Josep Trueta. Girona (España).
² Hospital Universitario Dr. Josep Trueta. Girona (España).
³ Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona (España). Correspondence: Enrique Llerena Santa Cruz. Email: santum7@yahoo.com
Palabras clave: terapia combinada; paracetamol; ibuprofeno; fiebre; esquema de medicación
Keywords: combined modality therapy; acetaminophen; ibuprofen; fever; drug administration schedule
Reception date: 03/02/2012   Acceptance date: 16/02/2012   Publication date: 22/02/2012   

Full Article in PDF and Spanish 

 http://ubuntuone.com/12dp7AVqkOznLuZymMAxjg

How to citate this article

Llerena Santa Cruz E, Guarch Ibáñez B, Buñuel Álvarez JC. No existen pruebas suficientes que avalen el uso de ibuprofeno y paracetamol combinados para el tratamiento de la fiebre. Evid Pediatr. 2012;8:18.

Bibliography

1. American Academy of Pediatrics. Fever and antipyretic use in children. Pediatrics. 2011;127:580-7.
2. National Institute for Health and Clinical Excellence. Feverish illness in children, assessment and initial management in children younger than 5 years. London: National Collaborating Centre for Women’s and Children’s Health; 2007.
3. Chiappini E, Principi N, Longhi R, Tovo PA, Becherucci P, Bonsignori F et al. Management of fever in children: summary of the Italian Pediatric Society guidelines. Clin Ther. 2009;31:1826-43. 
4. Esparza Olcina MJ. Eficacia y seguridad de ibuprofeno y paracetamol en niños y adultos: metanaanálisis y revisión cualitativa. Evid Pediatr. 2011;7:98.
5. Prymula R, Siegrist CA, Chlibek R, Zemlickova H, Vackova M, Smetana J et al. Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Lancet. 2009;374:1339-50.

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