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| Ovarian and breast cancer patients in a pedigree chart of a family (Photo credit: Wikipedia) |
Familial breast cancer occurs in people with one or more
family members affected by breast, ovarian, or a related cancer such as
primary peritoneal cancer. About 5% of all breast cancers can be
attributed to inherited mutations in specific high risk genes such as
BRCA1, BRCA2, and TP53.
This article summarises the most
recent recommendations from the National Institute for Health and Care
Excellence (NICE) on the classification and care of people at risk of
familial breast cancer.1 The guideline updates previous NICE guidance on familial breast cancer, published in 2004 and 2006.2 3
It also provides new guidance on men and women with a newly or
previously diagnosed breast cancer who have a family history of breast
and ovarian cancer, as they were excluded from previous guidance.4
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